Stillbirth with a chromosomal structural abnormality

Abstract

Objective: Study structural abnormalities of chromosome of stillbirth and associated chromosomal abnormalities that with parental chromosomes. Subjects and Methods: Consisting of 176 stillbirths were sampled villus to cell culture and chromosome analysis. Results: This report have shown that 7/176 (3,98%) cases of stillbirth with chromosomal structural abnormalities, in which six cases are pure and one case is mosaic. The chromosome translocation form is 85,7%, and the chromosome inversion form is 14,3%. Research shows that 50% of these abnormalities from maternal origin, 16,7 % are derived from the father and the remaining 33,3% are new mutations. Conclusion: Abnormal chromosome structure is one of the causes of stillbirth and often involves the available abnormal from their parents. The identify abnormal type of chromosome structure of stillbirths have an important role to couples with a history of multiple stillbirths in prognosis and genetic counseling for future pregnancies.