Research several chromosomal abnormalities in patients with amenorrhea

Abstract

Background: Amenorrhea is a symptom of many diseases in gynecological pathology. Amenorrhea often associated with infertility, so finding the cause amenorrhea is necessary for treatment to be able to get pregnant and have a baby. For some cases, amenorrhea is related to abnormal chromosome, especiallity with abnormality in X chromosome.

Objective: 1. Determine the ratio of chromosomal abnormalities in amenorrhea patients. 2. The first step to find out the correlation between chromosomal abnormalities and amenorrhea.

Subjects: 150 female patients with amenorrhea with age > 15 were examinated. Testing chromosomes were perfomed in Prenatal Diagnostic Center - National hospital of obstetrics and gynecology (NHOG) from 10/2010 - 3/2014.

Methods: A retrospective descriptive study. Study activities: making genetic medical records; Cell cultures of peripheral blood lymphocytes; Stained chromosome by banding G method; chromosome analysis and making karyotyp followed international standards ISCN 2013.

Results and conclusions: 1: Percentage of chromosome abnormalities in patients amenorrhea in 36/150 (24%), in which Turner syndrome is 19/36 (52.78%). Patients with testicular feminization syndrome are 17/36 (47.22%). 7 patients with Rokitansky syndrome with no chromosomal abnormalities. 2. The relationship between chromosomal abnormalities and amenorrhea: Turner syndrome: Prevalence primary amenorrhea is 18/19 (94.74%). Secondary amenorrhea is 1/19 (5.26%). Karyotyp mosaic is 4/19 (21.05%). The syndrome of testicular feminized: primary amenorrhea is 100%, karyotyp 46,XY is 100%.