Effects of estradiol therapy in vascular disorders and psychological disorders in post-menopausal women

Abstract

Objectives: Surveying vascular disorders and psychological disorders rate in post-menopausal women. Assessment effects of estradiol therapy in vascular disorders and psychological disorders in post-menopausal women.

Materials & methods: A cross-sectional study with surveying and community intervention of 264 post-menopausal women, not using hormone replacement therapy, there are signs of dysfunction, seen at hospital of Hue University of Medicine and Pharmacy from May to December, 2014. Data collection was implemented by conducting questionnaires with respondents and gynecological examination, ECG, breast ultrasound, endometrium ultrasound and Mammography. Participants without cardiovascular diseases and gynecological tumors, no phenomenon of thick membrane of the uterus, having symptoms of vascular disorders and psychological disorders will treated by estradiol 2mg (specific Cyclo-progynova). We selected 89 cases for treatment.

Results: Vascular disorders and psychological disorders rate in postmenopausal women: palpitation and memory loss: 87,6% and 84,6%, hot flash 43,8%, night sweats 56,2%, sleep disturbance 82,0%, feel dizzy 65,2%, irritability 78,7%, feeling tired 73,0%, lack of concentration 66,3%, bored 65,8%, cold hands and feet 24,7%. With eight weeks of estradiol therapy, symptoms of Vascular disorders and psychological disorders was significant improve: There are 2,6% (one case) still remaining hot flash in comparison with 43,8% cases at the beginning, 20,5% still remaining palpitation in comparision with 87,6% at the beginning, night sweats 2,0%, sleep disturbance 16,4%, irritability 17,1%, feeling tired 18,5%, lack of concentration 49,2%, boredom 31,1%, feel dizzy 29,3%, memory loss still high percentage 65,1%.

Conclusion: The incident of vascular disorders and psychological disorders in postmenopausal women is high and Estradiol has been proved could solve this problem significantly.