High-dose chemotherapy combined with targeted therapy supported by peripheral autologous stem cells transplantation in treatment of late stage and recurrent epithelial ovarian cancer
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Le, S. P., Nguyen, D. T., Chau, K. T., Bach, C. A., Le, M. T., Hoang, B. N., Dinh, thi P. M., & Phan, V. T. (2016). High-dose chemotherapy combined with targeted therapy supported by peripheral autologous stem cells transplantation in treatment of late stage and recurrent epithelial ovarian cancer. Vietnam Journal of Obstetrics & Gynecology, 14(3), 90-94. https://doi.org/10.46755/vjog.2016.3.755

Abstract

Objectves: 1) To study effectiveness of highdose chemotherapy combined with targeted therapy in treatment of late staged and recurrent ovarian cancer. 2) To study effectiveness of peripheral autologous stem cells transplantation in supporting patients after highdose chemotherapy.

Materials: 11 patients with late staged and recurrent ovarian cancer.

Methods: a seri-case study. Results: age of patients was 49.2±5.2. 4 patients had one cycles while had one cycle. Mean time of completed normalization of white blood cells was 7.6±0.8 days, and platelete was 9.6±2.2 days. Progressive free survival and overall survival were 19.3±5.6 months and 31.0±6.2 months.

Conclusions: Highdose chemotherapy combined with targeted was safe and effective.

Keywords

highdose chemotherapy, peripheral autologous stem cells transplatation, epithelial ovarian cancer.
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