Prediction of preeclampsia by arterial pressure at 11+0 to 13+6 weeks’ gestation

Abstract

Objective: To assess the performance of screening for (PE) by systolic blood pressure (BP), diastolic BP, and mean arterial pressure (MAP) at 11+0 to 13+6 weeks’ gestation.

Materials and methods: Prospective screening study for preeclampsia in pregnant attending their first hospital visit. The systolic BP, diastolic BP and MAP were measured and expressed as multiple of the median (MoM). The performance of screening for PE by maternal characteristics and systolic BP, diastolic BP, and MAP MoM at at 11+0 to 13+6 weeks’ gestation.

Results: The performance of screening for PE in 2.998 singleton pregnancies, there were 3.74% of hypertension disorder, and 2.84% cases of pre-eclampsia including 0.43% with early PE (requiring delivery < 34 weeks’ gestation) and 2.40% with late PE (delivering < 37 weeks’ gestation). The multiple of the median of systolic BP, diastolic BP, and MAP were significantly higher in early-PE and late-PE than in the controls. The best performance in screening was provided by MAP. In screening by maternal characteristics and MAP, at a false-positive rate of 10%, the detection rates of early-PE and late-PE were 63.5% and 35.1%, respectively.

Conclusion: The BP should be expressed as multiple of the median (MoM) after adjustment for related factors. The measurement of BP can be combined with the maternal factor to provide effective first-trimester screening for PE.