Hiệu quả hỗ trợ phôi thoát màng trong thụ tinh ống nghiệm

Abstract

Objective: To assess the effectiveness of laser assisted hatching technique (LAH) in fresh and frozen embryo transfer cycles of in-vitro fertilization.

Subject and methods: This is a cross-sectional descriptive retrospective study was conducted in Hue University Hospital of Medicine and Pharmacy at centre for Reproductive Endocrinology and Infertility in the period from December 2013 to June 2015. Two hundred patients who had indicated in-vitro fertilization were divided random into two groups using the method of thinning laser hatching (thinning group) or had no laser hatching (control group).

Results: A total of 220 transfer cycles with 986 embryos in which having 899 survival embryos occupying 91,2%. the rate of embryos G1 were 54,7%, embryos G2 was 23,3% and that were enrolled LAH before transfering embryos. The biochemical and clinical pregnancy rate were higher has statistically different when compare between fresh and frozen embryos transfer cycles. The clinical pregnancy rate of fresh embryo transfer cycles was 40,9% in thinning group compared 30,9% with control group, the ongoing pregnancies rate was 37,2% in thinning group compared 27,2% with control group. The patients who transferred the frozen embryo had the clinical pregnancy rate and ongoing pregnancy rate were higher than that when compare with control group respectively 34,5% vs18,1%; 30,9% vs 16,3%.

Conclusion: The results of this study demonstrated that assisted hatching by zona thinning increase the effectiveness of pregnancy rate in-vitro fertilization.