Effectiveness of long –acting fsh in ovarian stimulation in invitro fertilization

Abstract

The randomized clinical controlled trial study including 126 patients divided into 2 groups. Study group was stimulated by corifollitropin alfa (Elonva) with dose of 100 or 150 μg depending on patient’s weight below 60kg or above. Antagonist (orgalutran) were added on day 6 and 150 - 200IU rFSH supplemented on 8 if follicles unsatisfactory. The control group was stimulated with rFSH, theinitial dose dependedon ovarian reserve. Both groups were monitored follicle development by ultrasound and E2concentration. hCG injection when there were at least 3 follicles over 17mm diameter. Embryo transfer on day 3and luteal support with progesterone vaginally. The study results showed infertilitycharacteristicsand ovarian reserve in normal range and did not differ between the study and control groups. The fertilization rate, implantation rate and positive hCG rate equivalent in both control and study group but clinical pregnancy rate in study group was lower than that in control group.