Fetus with abnormal number chromosomes in Prenatal Diagnostic Center of National Hospital of Obstetrics and Gynecology in 2011-2012

Abstract

Chromosomal abnormalities can cause severe deformities and organ morphology leads to early death before birth, during birth or death after birth. Chromosome abnormalities may be the cause of the miscarriages, stillbirths. The screening and prenatal diagnosis will help to reduce the incidence of child bearing birth defects and perinatal death. Objective: (1)Detection of an unusual number of fetal chromosomes from cultured amniotic cells; (2) Rating value of prenatal screening tests to detect fetal chromosomal abnormalities. Subjects: 1865 women were diagnosed before birth. Research methodology: a description. Results and Conclusions: The results of amniocentesis by maternal serum screening was 53,30%, due to pregnancy ultrasound is 29,62%. Rate of chromosomal abnormalities encountered 6,77%, in which fetal Down syndrome have 3,44%, fetus with Edwards syndrome have 1,39%. Based on the results of maternal serum screening, the detection rate of fetus Down’s is 82,61%, fetus with Edward syndrome is 90,91%. Based fetal ultrasound to detect fetal Down ratio is 69,35%, detection rate of fetal gestational Edward and Patau syndrome is 100%, fetal Turner syndrome was 80%, with 49/101 fetal chromosomal abnormalities have increased nuchal translucency thick.