Predictive value of β-hCG at 14th days affter embryo transferation to IVF outcome

Abstract

Objective: To determine the value of βhCG level at 14th day after embryo transferation to in-vitro fertilization outcome.

Objects: This study conducted in 1228 IVF patients in National Assisted Reproductive Techonology Center-National hospital of Obstetrics and Gynecology from 2014 to 2015. Patients have βhCG blood test over 5 mIU/mL at 14th day after embryo transferation. Clinical pregnancy embryonic sac detected by transvaginal ultrasound after 4 weeks including ectopic pregnancy. Biochemical pregnancy: Level of βhCG is over 5 mIU/mL on day 14th after embryo transferation and no embryonic sac detected by vaginal ultrasound after 4 weeks (no clinical pregnancy). Methods: This was retrospective, cross-sectional method.

Results: Mean of gestational age was 31,4 ± 4,6. Mean of βhCG level among clinical pregnancy was 761,5 ± 706,33 mIU/mL; Mean of βhCG level among biochemical pregnancy was 161,02 ± 82,35 mIU/mL (p < 0,001). The βhCG cut-off value in clinical pregnancy was 299,5mIU/mL with sensitivity of 81%, specificity of 98% and that of biochemical pregnancy was 115,5 mIU/mL with 76% sensitivity, 95% specificity.

Conclusion: The βhCG cut-off value at 14th day after embryo transferation was valuable in predicting clincal pregnancy or biochemical pregnancy in IVF.