Assessment of unsuccessful treatment for gestational trophoblastic neoplasm patients in National Hospital of Obstetrics and Gynecology in 2016

Abstract

Gestational trophoblastic neoplasm can be cured mainly by chemotherapy and surgery with high success rate but there still are failures. Objective: to evaluate risk factor and possible causes of treatment failure for gestational trophoblastic neoplasm. Subjects: 5 failure cases among the 250 gestational trophoblastic neoplasm patients treated in 2016 at National Hospital of Obstetrics and Gynecology were included. Methodology: descriptive retrospective. Results: the rate of unsuccessful treatment for gestational trophoblastic neoplasm was 2%. All patients were at high risk group, 1 patient after term pregnancy, 4 patients after hydatidiform mole. 2 patients did not follow treatment and/or follow-up sufficiently. Most frequent metastatic position: lung, vagina, kidney and liver. At time of treatment cesation: 2 patients developed chemoresistance, 3 patients had serious side-effects. Conclusion: all treatment failures cases were high risk group according to WHO’s criteria; and are related related to lack of adherence, or inappropriate follow-up after treatment.