Abstract
Background: NMDAR antibody encephalitis appears rare in the world, the number of clinical cases in Vietnam which were recorded is rare.
Case report: we describe two new cases of disease in recent years with the aim of contributing to diagnosis and treatment experiences. These cases were noted over the past 3 years with the patients who have been treated at lower levels but have no results. They came to us when symptoms become worse and therefore required prolonged treatment with special intensive care facilities. The atypical and easily confused symptoms are the reasons that make the disease be detected late; leading to a much higher cost of treatment and the complication may appear in the patient. In the past, patients with these manifestations were diagnosed with unexplained encephalitis and severe sequelae or death. Autoimmune encephalitis has many types; NMDA encephalitis associated with ovarian teratoma is the most common autoimmune encephalitis in young women.
Conclusion: In conclusion, based on the case report, we hope to contribute some experiences on the diagnosis and the strategy in early treatment. With most female patients at a very young age, early treatments to avoid complications will help patients have a quality life and maintain reproductive function.
References
2. J. Dalmau, A. J. Gleichman, E. G. Hughes và cộng sự (2008). Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. The Lancet. Neurology, 7 (12), 1091-1098.
3. J. Dalmau, E. Lancaster, E. Martinez-Hernandez và cộng sự (2011). Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. The Lancet. Neurology, 10 (1), 63-74.
4. A. Uchino, T. Iizuka, Y. Urano và cộng sự (2011). Pseudo-piano playing motions and nocturnal hypoventilation in anti-NMDA receptor encephalitis: response to prompt tumor removal and immunotherapy. Internal medicine (Tokyo, Japan), 50 (6), 627-630.
5. H. Shimazaki, Y. Ando, I. Nakano và cộng sự (2007). Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus. J of neurology, neurosurgery and psychiatry, 78 (3), 324-325.
6. D. Wong và B. Fries (2014). Anti-NMDAR encephalitis, a mimicker of acute infectious encephalitis and a review of the literature. IDCases, 1 (4), 66-67.
7. Titulaer M. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013;12(2):157–165.
8. Mann A., Grebenciucova E., Lukas R. Anti- N-methyl-D-aspartate receptor encephalitis: diagnosis, optimal management, and challenges. Ther. Clin. Risk Manag. 2014;10:517-525.
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