Tóm tắt
Chlamydia trachomatis là một trong những tác nhân nhiễm khuẩn lây qua tình dục thường gặp nhất ở phụ nữ. Ngoài các hệ quả trên chức năng sinh sản, nhiễm Chlamydia trachomatis ở phụ nữ mang thai làm tăng nguy cơ gặp kết cục thai kỳ xấu, bao gồm ối vỡ non, sinh non, thai chết lưu, và trẻ sơ sinh nhẹ cân. D còn có thể lây truyền dọc từ mẹ sang con khi sinh ngả âm đạo, gây viêm kết mạc và viêm phổi ở trẻ sơ sinh, làm tăng thêm bệnh suất và tử suất sơ sinh. Dù có tiêu chuẩn chẩn đoán và quy trình tầm soát đơn giản, hiện nay vẫn chưa có nhiều khuyến cáo về tầm soát và quản lý Chlamydia trachomatis trên đối tượng là phụ nữ mang thai. Bài tổng quan này trình bày các bằng chứng cập nhật về đặc điểm lâm sàng, hệ quả, cũng như các phương thức tầm soát, chẩn đoán và chiến lược quản lý nhiễm Chlamydia trachomatis trong thai kỳ.
Từ khóa
Tài liệu tham khảo
1. Kostova EB, Prins JR, van Wely M. Role of infections in miscarriage. Fertility and Sterility. 2023;120(5):948-50.
2. Walker DG, Walker GJ. Forgotten but not gone: the continuing scourge of congenital syphilis. Lancet Infect Dis. 2002;2(7):432-6.
3. Brocklehurst P, French R. The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis. Br J Obstet Gynaecol. 1998;105(8):836-48.
4. Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Current Opinion in Infectious Diseases. 2008;21(1):70-6.
5. Baud D, Goy G, Jaton K, Osterheld MC, Blumer S, Borel N, et al. Role of Chlamydia trachomatis in miscarriage. Emerg Infect Dis. 2011;17(9):1630-5.
6. LaVerda D, Albanese LN, Ruther PE, Morrison SG, Morrison RP, Ault KA, et al. Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease. Infect Immun. 2000;68(1):303-9.
7. Rodgers AK, Wang J, Zhang Y, Holden A, Berryhill B, Budrys NM, et al. Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. Am J Obstet Gynecol. 2010;203(5):494.e7-.e14.
8. Mårdh P-A. Influence of infection with Chlamydia trachomatis on pregnancy outcome, infant health and life-long sequelae in infected offspring. Best Practice & Research Clinical Obstetrics & Gynaecology. 2002;16(6):847-64.
9. Xia Q, Wang T, Xian J, Song J, Qiao Y, Mu Z, et al. Relation of Chlamydia trachomatis infections to ectopic pregnancy: A meta-analysis and systematic review. Medicine (Baltimore). 2020;99(1):e18489.
10. Gencay M, Koskiniemi M, Ammälä P, Fellman V, Närvänen A, Wahlström T, et al. Chlamydia trachomatis seropositivity is associated both with stillbirth and preterm delivery. Apmis. 2000;108(9):584-8.
11. Baud D, Greub G. Intracellular bacteria and adverse pregnancy outcomes. Clin Microbiol Infect. 2011;17(9):1312-22.
12. Witkin SS, Neuer A, Giraldo P, Jeremias J, Tolbert V, Korneeva IL, et al. Chlamydia trachomatis Infection, Immunity, and Pregnancy Outcome. Infect Dis Obstet Gynecol. 1997;5(2):128-32.
13. Olson-Chen C, Balaram K, Hackney DN. Chlamydia trachomatis and Adverse Pregnancy Outcomes: Meta-analysis of Patients With and Without Infection. Matern Child Health J. 2018;22(6):812-21.
14. Adachi K, Nielsen-Saines K, Klausner JD. Chlamydia trachomatis Infection in Pregnancy: The Global Challenge of Preventing Adverse Pregnancy and Infant Outcomes in Sub-Saharan Africa and Asia. Biomed Res Int. 2016;2016:9315757.
15. Gao R, Liu B, Yang W, Wu Y, Wang B, Santillan MK, et al. Association of Maternal Sexually Transmitted Infections With Risk of Preterm Birth in the United States. JAMA Network Open. 2021;4(11):e2133413-e.
16. Ahmadi A, Ramazanzadeh R, Sayehmiri K, Sayehmiri F, Amirmozafari N. Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018;18(1):240.
17. Rours GIJG, Duijts L, Moll HA, Arends LR, de Groot R, Jaddoe VW, et al. Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study. European Journal of Epidemiology. 2011;26(6):493-502.
18. de Attayde Silva MJPM, Dantas Florêncio GL, Erbolato Gabiatti JR, do Amaral RL, Júnior JE, da Silveira Gonçalves AK. Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study. The Brazilian Journal of Infectious Diseases. 2011;15(6):533-9.
19. Liu B, Roberts CL, Clarke M, Jorm L, Hunt J, Ward J. Chlamydia and gonorrhoea infections and the risk of adverse obstetric outcomes: a retrospective cohort study. Sexually Transmitted Infections. 2013;89(8):672.
20. Folger AT. Maternal Chlamydia trachomatis infections and preterm birth:the impact of early detection and eradication during pregnancy. Matern Child Health J. 2014;18(8):1795-802.
21. Harb H, Al-Rshoud F, Karunakaran B, Gallos ID, Coomarasamy A. Hydrosalpinx and pregnancy loss: a systematic review and meta-analysis. Reprod Biomed Online. 2019;38(3):427-41.
22. Harb H, Al-rshoud F, Coomarasamy A. The effect of presence and management of hydrosalpinx on miscarriage in IVF. Fertility and Sterility. 2014;102(3):e298.
23. Hooker AB, J. MF, G. ER, and Frijmersum Z. Reproductive outcomes in women with mild intrauterine adhesions; a systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2022;35(25):6933-41.
24. Yu D, Wong YM, Cheong Y, Xia E, Li TC. Asherman syndrome--one century later. Fertil Steril. 2008;89(4):759-79.
25. Baradwan S, Baradwan A, Bashir M, Al-Jaroudi D. The birth weight in pregnant women with Asherman syndrome compared to normal intrauterine cavity: A case-control study. Medicine (Baltimore). 2018;97(32):e11797.
26. Smikle C YS, Khetarpal S. Asherman Syndrome: Treasure Island (FL): StatPearls Publishing; 2023 [Available from: https://www.ncbi.nlm.nih.gov/books/NBK448088/.
27. Basit H PA, Malik A, et al. Fitz-Hugh-Curtis Syndrome: Treasure Island (FL): StatPearls Publishing; 2023 [Available from: https://www.ncbi.nlm.nih.gov/books/NBK499950/.
28. Chlamydial Infections - Sexually Transmitted Infections Treatment Guidelines, 2021. Centers for Disease Control and Prevention. [Available from: https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm.
29. Wiesenfeld HC. Screening for Chlamydia trachomatis Infections in Women. N Engl J Med. 2017;376(8):765-73.
30. Tong H, Heuer A, Walker N. The impact of antibiotic treatment for syphilis, chlamydia, and gonorrhoea during pregnancy on birth outcomes: A systematic review and meta-analysis. J Glob Health. 2023;13:04058.
31. Adachi KN, Nielsen-Saines K, Klausner JD. Chlamydia trachomatis Screening and Treatment in Pregnancy to Reduce Adverse Pregnancy and Neonatal Outcomes: A Review. Front Public Health. 2021;9:531073.
32. Fan H, Li L, Wijlaars L, Gilbert RE. Associations between use of macrolide antibiotics during pregnancy and adverse child outcomes: A systematic review and meta-analysis. PLoS One. 2019;14(2):e0212212.
33. Zofkie AC, Fomina YY, Roberts SW, McIntire DD, Nelson DB, Adhikari EH. Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy. Am J Obstet Gynecol. 2021;225(3):325 e1- e7.
34. Dionne-Odom J, Subramaniam A, Aaron KJ, Geisler WM, Tita ATN, Marrazzo J. High rates of persistent and recurrent chlamydia in pregnant women after treatment with azithromycin. Am J Obstet Gynecol MFM. 2020;2(4):100216.
35. ACOG Committee Opinion No. 737: Expedited Partner Therapy. Obstet Gynecol. 2018;131(6):e190-e3.
36. Geisler WM, Hocking JS, Darville T, Batteiger BE, Brunham RC. Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. Clin Infect Dis. 2022;74(Suppl_2):S112-s26.
37. Cluver C, Novikova N, Eriksson DOA, Bengtsson K, Lingman GK. Interventions for treating genital Chlamydia trachomatis infection in pregnancy. Cochrane Database of Systematic Reviews. 2017(9).
2. Walker DG, Walker GJ. Forgotten but not gone: the continuing scourge of congenital syphilis. Lancet Infect Dis. 2002;2(7):432-6.
3. Brocklehurst P, French R. The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis. Br J Obstet Gynaecol. 1998;105(8):836-48.
4. Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Current Opinion in Infectious Diseases. 2008;21(1):70-6.
5. Baud D, Goy G, Jaton K, Osterheld MC, Blumer S, Borel N, et al. Role of Chlamydia trachomatis in miscarriage. Emerg Infect Dis. 2011;17(9):1630-5.
6. LaVerda D, Albanese LN, Ruther PE, Morrison SG, Morrison RP, Ault KA, et al. Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease. Infect Immun. 2000;68(1):303-9.
7. Rodgers AK, Wang J, Zhang Y, Holden A, Berryhill B, Budrys NM, et al. Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. Am J Obstet Gynecol. 2010;203(5):494.e7-.e14.
8. Mårdh P-A. Influence of infection with Chlamydia trachomatis on pregnancy outcome, infant health and life-long sequelae in infected offspring. Best Practice & Research Clinical Obstetrics & Gynaecology. 2002;16(6):847-64.
9. Xia Q, Wang T, Xian J, Song J, Qiao Y, Mu Z, et al. Relation of Chlamydia trachomatis infections to ectopic pregnancy: A meta-analysis and systematic review. Medicine (Baltimore). 2020;99(1):e18489.
10. Gencay M, Koskiniemi M, Ammälä P, Fellman V, Närvänen A, Wahlström T, et al. Chlamydia trachomatis seropositivity is associated both with stillbirth and preterm delivery. Apmis. 2000;108(9):584-8.
11. Baud D, Greub G. Intracellular bacteria and adverse pregnancy outcomes. Clin Microbiol Infect. 2011;17(9):1312-22.
12. Witkin SS, Neuer A, Giraldo P, Jeremias J, Tolbert V, Korneeva IL, et al. Chlamydia trachomatis Infection, Immunity, and Pregnancy Outcome. Infect Dis Obstet Gynecol. 1997;5(2):128-32.
13. Olson-Chen C, Balaram K, Hackney DN. Chlamydia trachomatis and Adverse Pregnancy Outcomes: Meta-analysis of Patients With and Without Infection. Matern Child Health J. 2018;22(6):812-21.
14. Adachi K, Nielsen-Saines K, Klausner JD. Chlamydia trachomatis Infection in Pregnancy: The Global Challenge of Preventing Adverse Pregnancy and Infant Outcomes in Sub-Saharan Africa and Asia. Biomed Res Int. 2016;2016:9315757.
15. Gao R, Liu B, Yang W, Wu Y, Wang B, Santillan MK, et al. Association of Maternal Sexually Transmitted Infections With Risk of Preterm Birth in the United States. JAMA Network Open. 2021;4(11):e2133413-e.
16. Ahmadi A, Ramazanzadeh R, Sayehmiri K, Sayehmiri F, Amirmozafari N. Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018;18(1):240.
17. Rours GIJG, Duijts L, Moll HA, Arends LR, de Groot R, Jaddoe VW, et al. Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study. European Journal of Epidemiology. 2011;26(6):493-502.
18. de Attayde Silva MJPM, Dantas Florêncio GL, Erbolato Gabiatti JR, do Amaral RL, Júnior JE, da Silveira Gonçalves AK. Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study. The Brazilian Journal of Infectious Diseases. 2011;15(6):533-9.
19. Liu B, Roberts CL, Clarke M, Jorm L, Hunt J, Ward J. Chlamydia and gonorrhoea infections and the risk of adverse obstetric outcomes: a retrospective cohort study. Sexually Transmitted Infections. 2013;89(8):672.
20. Folger AT. Maternal Chlamydia trachomatis infections and preterm birth:the impact of early detection and eradication during pregnancy. Matern Child Health J. 2014;18(8):1795-802.
21. Harb H, Al-Rshoud F, Karunakaran B, Gallos ID, Coomarasamy A. Hydrosalpinx and pregnancy loss: a systematic review and meta-analysis. Reprod Biomed Online. 2019;38(3):427-41.
22. Harb H, Al-rshoud F, Coomarasamy A. The effect of presence and management of hydrosalpinx on miscarriage in IVF. Fertility and Sterility. 2014;102(3):e298.
23. Hooker AB, J. MF, G. ER, and Frijmersum Z. Reproductive outcomes in women with mild intrauterine adhesions; a systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2022;35(25):6933-41.
24. Yu D, Wong YM, Cheong Y, Xia E, Li TC. Asherman syndrome--one century later. Fertil Steril. 2008;89(4):759-79.
25. Baradwan S, Baradwan A, Bashir M, Al-Jaroudi D. The birth weight in pregnant women with Asherman syndrome compared to normal intrauterine cavity: A case-control study. Medicine (Baltimore). 2018;97(32):e11797.
26. Smikle C YS, Khetarpal S. Asherman Syndrome: Treasure Island (FL): StatPearls Publishing; 2023 [Available from: https://www.ncbi.nlm.nih.gov/books/NBK448088/.
27. Basit H PA, Malik A, et al. Fitz-Hugh-Curtis Syndrome: Treasure Island (FL): StatPearls Publishing; 2023 [Available from: https://www.ncbi.nlm.nih.gov/books/NBK499950/.
28. Chlamydial Infections - Sexually Transmitted Infections Treatment Guidelines, 2021. Centers for Disease Control and Prevention. [Available from: https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm.
29. Wiesenfeld HC. Screening for Chlamydia trachomatis Infections in Women. N Engl J Med. 2017;376(8):765-73.
30. Tong H, Heuer A, Walker N. The impact of antibiotic treatment for syphilis, chlamydia, and gonorrhoea during pregnancy on birth outcomes: A systematic review and meta-analysis. J Glob Health. 2023;13:04058.
31. Adachi KN, Nielsen-Saines K, Klausner JD. Chlamydia trachomatis Screening and Treatment in Pregnancy to Reduce Adverse Pregnancy and Neonatal Outcomes: A Review. Front Public Health. 2021;9:531073.
32. Fan H, Li L, Wijlaars L, Gilbert RE. Associations between use of macrolide antibiotics during pregnancy and adverse child outcomes: A systematic review and meta-analysis. PLoS One. 2019;14(2):e0212212.
33. Zofkie AC, Fomina YY, Roberts SW, McIntire DD, Nelson DB, Adhikari EH. Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy. Am J Obstet Gynecol. 2021;225(3):325 e1- e7.
34. Dionne-Odom J, Subramaniam A, Aaron KJ, Geisler WM, Tita ATN, Marrazzo J. High rates of persistent and recurrent chlamydia in pregnant women after treatment with azithromycin. Am J Obstet Gynecol MFM. 2020;2(4):100216.
35. ACOG Committee Opinion No. 737: Expedited Partner Therapy. Obstet Gynecol. 2018;131(6):e190-e3.
36. Geisler WM, Hocking JS, Darville T, Batteiger BE, Brunham RC. Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. Clin Infect Dis. 2022;74(Suppl_2):S112-s26.
37. Cluver C, Novikova N, Eriksson DOA, Bengtsson K, Lingman GK. Interventions for treating genital Chlamydia trachomatis infection in pregnancy. Cochrane Database of Systematic Reviews. 2017(9).
Công trình này được cấp phép theo Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. .
Download
Dữ liệu downlad không hiện hữu.