Research on clinical pregnancy rate and some factors related to IVF outcomes in women with polycystic ovary syndrome at Can Tho Obstetrics and Gynecology Hospital
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Cách trích dẫn

Nguyen, T. H., Nguyen, T. T. D., Le, H. T., Vo, T. K. Q., & Le, T. T. A. (2024). Research on clinical pregnancy rate and some factors related to IVF outcomes in women with polycystic ovary syndrome at Can Tho Obstetrics and Gynecology Hospital . Tạp Chí Phụ sản, 22(2), 59-67.

Tóm tắt

Objectives: To describe clinical and subclinical characteristics, to determine the clinical pregnancy rate, and to  analyze some factors related to in vitro fertilization (IVF) outcomes in women with polycystic ovary syndrome  (PCOS) at Can Tho Gynecology Obstetrics Hospital.  

Materials and methods: A cross-sectional descriptive study was conducted on 95 infertile women diagnosed with  PCOS according to Rotterdam criteria, underwent IVF cycles at the Fertility department of Can Tho Gynecology  Obstetrics hospital from April 2023 to September 2023. The baseline characteristics of PCOS were described  and IVF outcomes of research subjects were evaluated. Some factors related to clinical pregnancy rate were also  analyzed. 

Results: The average age of the study subjects was 29.9 ± 4.5 years old. The overweight rate was 11.6%. The  symptoms of women with PCOS include hyperandrogenism (16.8%); oligomenorrhea (71.6%), and amenorrhea  (1.1%); The image of polycystic ovaries on ultrasound in 1 ovary was 14.7%, whereas in 2 ovaries was 72.6%.  The average AMH concentration was 6.8 ± 4.4 ng/ml. Primary infertility and secondary infertility accounted for  58.9% and 41.1% respectively. The βhCG (+) rate and clinical pregnancy rate were 62.1% and 57.9%, respectively.  The rate of ovarian hyperstimulation was 8.4% (8 cases), of which mild ovarian hyperstimulation was 75% and  moderate severity was 25%. The multiple pregnancy rate was 38.2%, and the miscarriage rate was 2.1%. There was  no statistically significant difference between the clinical pregnancy rate and several factors such as age, BMI, type  of infertility, hyperandrogenism, number of follicles aspirated, number of embryos transferred to the uterus, number  of day-3 embryos, number of day-5 embryos, ovarian hyperstimulation. 

Conclusion: Women with PCOS have common characteristic disorders such as menstrual disorders,  hyperandrogenism, and polycystic ovary images on ultrasound. Research showed that the clinical pregnancy rate  in women with PCOS undergoing IVF was 57.9%. 

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Tài liệu tham khảo

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